Medical use of dimethyl sulfoxide (DMSO).
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Dimethyl sulfoxide DMSO is currently used as an alternative treatment for various inflammatory conditions as well as for cancer. Despite its widespread use, there is a paucity of data regarding its safety and efficacy as well as its mechanism of action in human cells. Specifically, we found that between 0. Thus, while we cannot confirm the efficacy of DMSO as an anti-cancer agent, the use of DMSO in arthritis warrants further investigation to ascertain its therapeutic potential. Dimethyl sulfoxide DMSO, i. It is widely available and inexpensive because it is easily generated from dimethyl sulfide DMS , a byproduct of the pulp and paper industry [ 3 ]. DMSO has also been used for many years to cryopreserve cells for both research and clinical applications since it prevents ice crystal formation and thus reduces cell death [ 4 ].
AS with many other unproved substances with seemingly miraculous properties, DMSO has been dubbed alternately a panacea and a snake oil. The drug has also attracted a considerable cult following, enormous journalistic attention and highly profitable sales for unapproved uses. The Food and Drug Administration has approved DMSO for only one medical use: to relieve the pain of a rare bladder disorder called interstitial cystitis. However, since DMSO is legally sold over the counter as an industrial chemical as well as by veterinarian's prescription for a few animal problems , the Federal Government cannot stop people from buying and applying it for myriad conditions ranging in seriousness from sprained ankles to cancer. It is most popular among professional athletes, who use it as a chemical hot-water bottle and contend that it gets them back into play within days of an injury; without it, they say, they have to sit on the sidelines for weeks while nature takes its time in healing. Patients suffering the crippling pain of arthritis have also given it considerable grass-roots support, although the Arthritis Foundation has repeatedly said that evidence of DMSO's effectiveness is lacking and has warned against unsupervised use of nonmedical preparations of DMSO. In the 's it was developed commercially as an antifreeze and a solvent for paints, synthetic fibers and household cleaners.
Two decades ago, if you mentioned dimethyl sulfoxide DMSO around the barn you may have gotten puzzled looks in response. Back then, this industrial solvent turned anti- inflammatory therapy was relatively new to the horse world, and even if people had heard of it they viewed it as an unusual or even mysterious option.
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The story of dimethyl sulfoxide DMSO is an unusual one. This by-product of the paper making process was discovered in Germany in the late 19th century. Scientists discovered that they could use DMSO as a transportation device to pass small molecules through skin. Since then, scientists have researched the potential benefits and risks of using DMSO to treat a variety of conditions. This research is ongoing. Some doctors began to use DMSO to treat cases of skin inflammation and diseases such as scleroderma because of its ability to penetrate skin.
Dimethyl sulfoxide is a chemical compound which is a by-product of wood processing. This DMSO pain relief is soluble in all proportions in water and also in alcohol and ether. It freezes at room temperature 65 degrees F and contains aloe vera. This does not affect product quality. It is often mixed with other extracts to enhance absorption.
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DMSO is a clear odorless liquid, inexpensively produced as a by-product of the paper industry. It is widely available in the USA as a solvent but its medical use is currently restricted by the FDA to the palliative treatment of interstitial cystitis and to certain experimental applications. Cutaneous manifestations of scleroderma appear to resolve albeit equivocally following topical applications of high concentrations of DMSO. A limited number of small clinical trials indicate that intravenous DMSO may be of benefit in the treatment of amyloidosis, possibly by mobilizing amyloid deposits out of tissues into urine. Dermal application of DMSO seems to provide rapid, temporary, relief of pain in patients with arthritis and connective tissue injuries. However, claims for antiinflammatory effects or acceleration of healing are currently unwarranted.